Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing
Daily dose of fluconazole is the same for oral and IV administration unless otherwise specified
Candida infections both mucocutaneous and invasive - i.e. Candidemia
Cryptococcus and Coccidioides infections
Antifungal prophylaxis in immunocompromised
Consider QTc monitoring if concomitant drugs affecting the interval or elevated baseline measurement
Hepatic enzyme abnormalities
Many via CYP450 - suggest review interactions with pharmacist.
Risk when combining with other QTc prolonging medications
Concentration: 10 mg/mL
Not all strengths of oral liquids are listed nor are available on IWK formulary
50 mg tablet
100 mg tablet
Tablets and capsules are preferred especially over an unpleasant tasting liquid.
Not all strengths of oral tablets/capsules are listed and they are not all available on the IWK formulary.
Antimicrobial class: Triazole antifungal
Average serum half life:
Premature neonates: 47-73.6 hours.
Pediatrics (9 months to 15 years): oral 19.5-25 hours
5- 15 years: IV 15-18 hours
Adults: Normal renal function: ~30 hours
Route of Elimination: 80% unchanged in urine; 11% metabolites in urine.