Loading dose, all neonates
A loading dose of 25 mg/kg/dose IV/PO x 1 dose may be considered in select neonates with suspected or confirmed systemic Candidiasis with any of the following risk factors:
Documented Candidiasis or Clinically Suspected Invasive Candidal Infection, corrected gestational age less than or equal to 29 weeks
12 mg/kg/dose IV/PO q48h
12 mg/kg/dose IV/PO q24h
Documented Candidiasis or Clinically Suspected Invasive Candidal Infection, corrected gestational age greater than or equal to 30 weeks
12 mg/kg/dose IV/PO q48h
12 mg/kg/dose IV/PO q24h
Prophylaxis for Prevention of Invasive Candidiasis
Starting on day 3 of life: 3 mg/kg/dose IV/PO q72h and continue until 6 weeks of age or until IV access no longer required.
Thrush, gestational age less than or equal to 29 weeks
6 mg/kg/dose IV/PO on day 1, followed by 3 to 6 mg/kg/dose IV/PO q72h ; change to q24h once beyond the first 2 weeks of life
6 mg/kg/dose IV/PO on day 1, followed by 3 to 6 mg/kg/dose IV/PO q24h
Thrush, gestational age greater than or equal to 30 weeks
6 mg/kg/dose IV/PO on day 1, followed by 3 to 6 mg/kg/dose IV/PO q24h