Cloxacillin

C. diff Risk

Medium

Oral Bioavailability

None

Approximate Cost

$10/day

Dosing

General Pediatric

100-200 mg/kg/24h IV divided q6h
Maximum: 12 g/24h

Other

For oral therapy: consider oral cephalexin as alternative as oral cloxacillin is poorly absorbed and must be administered on an empty stomach in frequent doses.

General Information

Common Usage

Treatment of sensitive MSSA and CoNS infections

Drug Monitoring

Renal and hepatic function
CBC with differential
Diarrhea

Adverse Effects

  • allergy (immediate or delayed)

  • phlebitis (IV)

  • cytopenias

  • eosinophilia

  • interstitial nephritis

  • abnormal liver enzymes

Pharmacology

Antimicrobial class: Antistaphylococcal penicillin

Route of Elimination: urine and feces

Average serum half life: Adults:0.5-1.5 h (prolonged in renal impairment and in neonates)