250-500 mg PO q12h
10-40 mg/kg/24h IV divided q12h
Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.
Cystic fibrosis, Pseudomonal infection
Renal and liver function
QTc in patients with increased risk
Tendinopathy and rupture have been reported.
Nausea, vomiting, abdominal pain
Tendinopathy and rupture
QTc prolongation have been reported
Strong CYP1A2 inhibitor and weak CYP3A4 inhibitor - Multiple interactions possible
QTc prolongation - Increased risk with other agents that prolong QTc
Increased risk of tendon rupture especially with concomitant use of corticosteroids.
Monitor INR with warfarin.
Avoid concurrent oral administration with calcium, antacids, iron. Administer ciprofloxacin 2 hours before or 4 hours after dose of calcium, antacids and iron.
Ciprofloxacin suspension should never be given through an enteral feeding tube. Ciprofloxacin immediate-release tablets can be given via tube, but should not be administered concurrently with enteral feedings. Discontinue feed for 1-2 hours prior to and after ciprofloxacin administration.
Not first-line therapy in children.
Antimicrobial class: Fluoroquinolone
Route of Elimination: 30% to 50% excreted as unchanged drug in urine via glomerular filtration and active tubular secretion;
20% to 40% excreted in feces primarily from biliary excretion;
<1% excreted in bile as unchanged drug
Average serum half life: Pediatrics: 4-5 hours