Amoxicillin

C. diff Risk

Low

Oral Bioavailability

Excellent

Approximate Cost

$0.50/day

Dosing

General Pediatric

Low dose: 45-60 mg/kg/24h PO divided q8h
High dose: 75-90* mg/kg/24h PO divided q8h. High dose can be divided q12h for otitis media.
Maximum: 4 g/24h
*use higher dose for CAP if patient has any of the following risk factors for resistant Streptococcus pneumoniae :
Unimmunized or incompletely immunized, daycare attendance, use of antibiotics in the preceding 3 months, failure of initial therapy

Adult

500 mg PO q8h (Urinary tract infection)
1000 mg PO q8h (Community acquired pneumonia in pregnancy)

Neonatal

20-30 mg/kg/24h PO divided q12h

General Information

Common Usage

Therapy of streptococcal, enterococcal infections as well as susceptible gram negative infections. Commonly used for upper respiratory infections and urinary tract infection (when organisms susceptible)

Adverse Effects

  • Allergy/rash (immediate or delayed)

  • Cytopenias

  • EBV related rash (not allergy)

Pharmacology

Antimicrobial class: Aminopenicillin

Route of Elimination: Renal excretion (60% unchanged drug)

Average serum half life: Neonates, full-term: 3.7 hours
Infants and children: 1 to 2 hours