Antimicrobials
Ertapenem

Ertapenem

Restricted

Medium
N/A
$50/day

Spectrum of Activity

General Information

Targeted therapy of ESBL infections and other resistant gram negative infections. Empiric therapy when broad spectrum of carbapenems is desired without the need for anti-pseudomonal activity

  • Renal Function

  • Hepatic function

  • CBC

  • Immediate and delayed-type allergy

  • GI disturbance

  • Cytopenias, eosinophilia, positive Coombs

  • Liver enzyme abnormalities

ID consult recommended. Doesn't reliably penetrate CNS therefore not recommended for meningitis.

Antimicrobial class: Carbapenem

Average serum half life:

  • Infants 3 months and older, and children: 2.5hrs

  • Adolescents and Adults: 4 hrs

Route of Elimination:

  • Non-CYP-mediated hydrolysis to inactive metabolite.

  • Urine (80%(38% as unchanged drug)) and feces (10%)