Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.
3 Months to 12 Years15 mg/kg/dose IV q12h
Greater than 12 Years1 g IV q24h
Targeted therapy of ESBL infections and other resistant gram negative infections. Empiric therapy when broad spectrum of carbapenems is desired without the need for anti-pseudomonal activity
Immediate and delayed-type allergy
Cytopenias, eosinophilia, positive Coombs
Liver enzyme abnormalities
ID consult recommended. Doesn't reliably penetrate CNS therefore not recommended for meningitis.
Antimicrobial class: Carbapenem
Average serum half life:
Infants 3 months and older, and children: 2.5hrs
Adolescents and Adults: 4 hrs
Route of Elimination:
Non-CYP-mediated hydrolysis to inactive metabolite.
Urine (80%(38% as unchanged drug)) and feces (10%)