Cefprozil

C. diff Risk

Medium

Oral Bioavailability

Excellent

Approximate Cost

4$/d

Dosing

General Pediatric

15-30 mg/kg/24h PO divided q12h
Maximum: 1 g/24h
*use higher dose for otitis media and community-acquired pneumonia

Adult

500 mg PO q12h

Renal

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing

General Information

Common Usage

Community-acquired pneumonia, otitis media, uncomplicated skin and skin structure infections

Adverse Effects

  • Allergy (cefprozil and amoxicillin have the same side chain, hence cross -allergenicity may occur)

  • Positive Coombs

  • Cytopenias

  • GI upset, diarrhea

  • Abnormal liver enzymes

Pharmacology

Antimicrobial class: 2nd Generation Cephalosporin