Oseltamivir

C. diff Risk

None

Oral Bioavailability

Excellent

Approximate Cost

$8/day

Dosing

Renal

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.

General Information

Common Usage

Treatment and prophylaxis of influenza

Adverse Effects

  • GI upset common

  • Rare - Stevens Johnson Syndrome

  • Neuropsychiatric side effects reported

Additional Information

Treatment should ideally begin within 48 hours

Pharmacology

Antimicrobial class: Antiviral - neuraminidase inhibitor

Route of Elimination: Hepatically metabolixed to >99% of oseltamivir carboxylate (active metabolite) is eliminated by renal excretion via glomerular filtration and tubular secretion

Average serum half life: No pediatric data available.
Adult: Oseltamivir phosphate: 1-3 hours, oseltamivir carboxylate: 6-10 hours