Oseltamivir

C. diff Risk

None

Oral Bioavailability

Excellent

Approximate Cost

$8/day

Dosing

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.

General Information

Common Usage

Treatment and prophylaxis of influenza

Adverse Effects

  • GI upset

  • Neuropsychiatric side effects reported in Japan

Oral Liquids

Concentration: 6 mg/mL
Taste: palatable
Not all strengths of oral liquids are listed nor are available on IWK formulary

Tablet/Capsule Strengths

75 mg capsule
Tablets and capsules are preferred especially over an unpleasant tasting liquid.
Not all strengths of oral tablets/capsules are listed and they are not all available on the IWK formulary.

Additional Information

Treatment should ideally begin within 48 hours

Pharmacology

Antimicrobial class: Antiviral - neuraminidase inhibitor

Average serum half life: No pediatric data available.
Adult: Oseltamivir phosphate: 1-3 hours, oseltamivir carboxylate: 6-10 hours

Route of Elimination: Hepatically metabolixed to >99% of oseltamivir carboxylate (active metabolite) is eliminated by renal excretion via glomerular filtration and tubular secretion