Vancomycin (oral)

C. diff Risk

None

Oral Bioavailability

None

Approximate Cost

$6/day

General Information

Common Usage

Only indication is in the therapy of C. difficile infection, particularly recurrent or severe disease

Drug Monitoring

Possibility of accumulation in severe renal dysfunction; consider checking a vancomycin level in dialysis patients

Major Interactions

Avoid concurrent administration of oral vancomycin and bile acid sequestrants (may diminish therapeutic effect of vancomycin).

Additional Information

No oral absorption. May increase vancomycin resistant enterococci colonization in the gut

Pharmacology

Antimicrobial class: glycopeptide

Route of Elimination: Primarily feces as limited absorption

Average serum half life: serum half life not available due to low systemic absorption