Vancomycin (oral)

C. diff Risk

None

Oral Bioavailability

None

Approximate Cost

$6/day

General Information

Common Usage

Only indication is in the therapy of C. difficile infection, particularly recurrent or severe disease

Drug Monitoring

Possibility of accumulation in severe renal dysfunction; consider checking a vancomycin level in dialysis patients

Major Interactions

Avoid concurrent administration of oral vancomycin and bile acid sequestrants (may diminish therapeutic effect of vancomycin).

Oral Liquids

Concentration: 25 mg/mL (compounded)
Taste: metallic taste
Not all strengths of oral liquids are listed nor are available on IWK formulary

Tablet/Capsule Strengths

125 mg capsule
Tablets and capsules are preferred especially over an unpleasant tasting liquid.
Not all strengths of oral tablets/capsules are listed and they are not all available on the IWK formulary.

Additional Information

No oral absorption. May increase vancomycin resistant enterococci colonization in the gut

Pharmacology

Antimicrobial class: glycopeptide

Average serum half life: serum half life not available due to low systemic absorption

Route of Elimination: Primarily feces as limited absorption