6 Months - 5 Years
8-10 mg/kg/dose IV/PO q12h
5 + Years
8-10 mg/kg/dose IV/PO q24h
Maximum: 750 mg/dose
500-750 mg IV/PO q24h
Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.
Monitor QTc in patients with increased risk
Nausea & Vomiting
Tendinopathy and rupture have been reported
QTc prolongation have been reported
Increased risk when combined with other QTc prolonging agents.
AVOID concomitant administration with antacids, multivitamin & mineral supplements. Space doses by 2 hours.
Increased risk of tendon rupture especially with concomitant use of corticosteroids.
Monitor INR with warfarin.
Dosing for oral and IV levofloxacin is identical
Not to be given IM or SC administration.
Antimicrobial class: Fluoroquinolone
Average serum half life:
Infants ≥6 months to 5 years: ~4 hours.
Children 5-16 years: 4.8-6 hours.
Adults: 6-8 hours
Route of Elimination: 87% excreted unchanged in urine over 48 hours by tubular secretion and glomerular filtration; 4% in feces