Piperacillin-Tazobactam

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

$30/day

Dosing

Adult

Preferred Dosing:
3 grams* IV q6h

*Injection 3/ 0.375 g vial containing: 3 g piperacillin and 0.375 g tazobactam

OR
Alternate Dosing:
4 grams* IV q8h

*Injection 4/ 0.5 g vial containing: 4 g piperacillin and 0.5 g tazobactam

Renal

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.

General Information

Common Usage

Broad spectrum agent with anti-pseudomonal activity used for severe infections including:

  • Pneumonia

  • Intra-abdominal/hepatobiliary

  • Polymicrobial skin and soft tissue infection

  • Febrile neutropenia

Drug Monitoring

  • Renal and hepatic function

  • CBC with differential

  • C. difficile-associated diarrhea

  • Hypersensitivity reactions

Adverse Effects

  • Allergy/rash (immediate or delayed)

  • Cytopenias- esp. thrombocytopenia, eosinophilia

  • Interstitial nephritis

  • Abnormal liver enzymes