Dosage adjustment in severe renal impairment only. Consult with a pharmacist for renal dosing
Suspected or confirmed anaerobic infections including intra-abdominal, biliary, central nervous system,
Clostridium difficile, Giardia and gynecoogical infections
Also used in Crohn's disease and bacterial vaginosis.
With prolonged therapy (>6wks) or if symptoms develop assess for peripheral/optic neuropathy
GI symptoms common- especially nausea and vomiting and metallic taste
Peripheral and or optic neuropathy with extended therapy
Disulfiram-like reaction (severe vomiting)
Rare neurotoxicity including aseptic meningitis and encephalopathy
Disulfiram reaction wtih alcohol or alcohol-containing medications/products.
Concentration: 50 mg/mL (compounded)
Taste: less palatable, unpleasant taste
Not all strengths of oral liquids are listed nor are available on IWK formulary
250 mg tablet
Tablets and capsules are preferred especially over an unpleasant tasting liquid.
Not all strengths of oral tablets/capsules are listed and they are not all available on the IWK formulary.
Antimicrobial class: Nitroimidazole
Average serum half life:
Neonates <7 days: (prolonged with lower GA) 24.8-75.3 hours.
Neonates ≥7 days: ~22.5 hours
Children and adolescents: 6-10 hours.
Adults: 8 hours
Route of Elimination:
urine (unchanged drug and metabolites: 60-80%; ~20% of total as unchanged drug)