Dosage adjustment in severe renal impairment only. Consult with a pharmacist for renal dosing
Suspected or confirmed anaerobic infections including intra-abdominal, biliary, central nervous system,
Clostridium difficile, Giardia and gynecoogical infections
Also used in Crohn's disease and bacterial vaginosis.
With prolonged therapy (>6wks) or if symptoms develop assess for peripheral/optic neuropathy
GI symptoms common- especially nausea and vomiting and metallic taste
Peripheral and or optic neuropathy with extended therapy
Disulfiram-like reaction (severe vomiting)
Rare neurotoxicity including aseptic meningitis and encephalopathy
Disulfiram reaction wtih alcohol or alcohol-containing medications/products.
Antimicrobial class: Nitroimidazole
Average serum half life:
Neonates <7 days: (prolonged with lower GA) 24.8-75.3 hours.
Neonates ≥7 days: ~22.5 hours
Children and adolescents: 6-10 hours.
Adults: 8 hours
Route of Elimination:
urine (unchanged drug and metabolites: 60-80%; ~20% of total as unchanged drug)