Tobramycin
Neonatal

Neonatal

Corrected Gestational Age Less Than Or Equal To 29 Weeks OR Significant Asphyxia, OR PDA Treatment With Indomethacin or Ibuprofen**

EXTENDED INTERVAL INITIAL DOSING. Dosage adjustments are made based on serum concentrations, clinical response and renal function (see "Drug Monitoring").
Post natal age less than or equal to 7 days

5 mg/kg/dose IV q48h

Post natal age 8 to 28 days

4 mg/kg/dose IV q36h

Post natal age greater than or equal to 29 days

4 mg/kg/dose IV q24h

Corrected Gestational Age 30 to 34 Weeks

EXTENDED INTERVAL INITIAL DOSING. Dosage adjustments are made based on serum concentrations, clinical response and renal function (see "Drug Monitoring").
Post natal age less than or equal to 7 days

4.5 mg/kg/dose IV q36h

Post natal age greater than or equal to 8 days

4 mg/kg/dose IV q24h

Corrected Gestational Age Greater Than 35 Weeks

EXTENDED INTERVAL INITIAL DOSING. Dosage adjustments are made based on serum concentrations, clinical response and renal function (see "Drug Monitoring").

4 mg/kg/dose IV q24h