Greater than 3 months
70 mg/m²/dose IV x 1 dose
Maximum loading dose: 70 mg/dose
Maintenance dose :
50 mg/m²/dose IV q24h
May increase to 70 mg/m²/dose IV q24h if clinical response is inadequate or in patients who are receiving enzyme inducers.
Maximum maintenance dose: 50 mg/dose
No dosage adjustment required in patients with renal impairment
Therapy of suspected and confirmed invasive fungal infections
Periodic liver function tests, renal function tests, CBC with differential
Increased liver enzymes, elevated bilirubin
GI upset, diarrhea
Pruritis, fever (most common in pediatrics)
Cyclosporin and tacrolimus (drug level monitoring recommended)
Pentrates poorly into CSF and urine.
Antimicrobial class: Echinocandin