Caspofungin

Restricted
Restricted

C. diff Risk

Low

Oral Bioavailability

NA

Approximate Cost

$100/day

Spectrum Of Activity

Dosing

No dosage adjustment required in patients with renal impairment

25 mg/m²/dose IV q24 h

General Information

Common Usage

Therapy of suspected and confirmed invasive fungal infections

Drug Monitoring

Periodic liver function tests, renal function tests, CBC with differential

Adverse Effects

Increased liver enzymes, elevated bilirubin
GI upset, diarrhea
Pruritis, fever (most common in pediatrics)

Major Interactions

Cyclosporin and tacrolimus (drug level monitoring recommended)

Additional Information

Pentrates poorly into CSF and urine.

Pharmacology

Antimicrobial class: Echinocandin