30-50 mg/kg/24h PO divided q6-8h
Maximum: 2 g/24h
15-50 mg/kg/24h IV divided q6h
Maximum: 4 g/24h
250 -500 mg PO q6h
Pertussis, Chlamydial infections, mycobacterial infections, latency in pregnancy
Monitor QTc in patients with increased risk.
GI upset, diarrhea
Prolongation of QTc interval
Substrate of CYP3A4. Multiple CYP450 interactions possible - consult a pharmacist for more detail. May increase digoxin, carbamazepine level. Caution with QTc prolonging medications
Erythromycin use has been associated with an increased risk of hypertrophic pyloric stenosis in term infants less than 14 days of age.
Antimicrobial class: Macrolide
Route of Elimination: Primarily hepatic