cefepime

C. diff Risk

High

Oral Bioavailability

NA

Approximate Cost

$85/day

Dosing

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.

General Information

Common Usage

Empiric Therapy for Febrile Neutropenia in patients who have a penicillin allergy or who are clearing methotrexate

Adverse Effects

Allergy (immediate or delayed), eosinophilia, thrombocytopenia, neutropenia
Transient liver function test increase, diarrhea

Pharmacology

Antimicrobial class: Parenteral cephalosporin 4th generation

Average serum half life: 1.7 hours

Route of Elimination: Renal clearance (60 % unchanged)