Acyclovir General Pediatric

HSV Mucocutaneous/Gingivostomatitis

5-10 mg/kg/dose IV q8h x 5-7 days
(Duration up to 14 days if immunocompromised)
Use lower dose if immunocompetent, use higher dose if immunocompromised.

80 mg/kg/24h PO divided in 3-4 doses x 5-7 days (or up to 14 days if immunocompromised)
Maximum: PO 800 mg /24h (200 mg q6h) if mild to moderate and PO 1.6 grams /24h (400 mg q6h) if severe.

For chronic suppression for recurrent episodes in immunocompetent patients; some experts recommend 20 mg/kg/dose PO every 8-12 hours for 6 to 12 months, then re-evaluate need.
Maximum: PO 400 mg/dose.

Varicella/Zoster

10 mg/kg/dose IV q8h
Doses as high as 15 mg/kg/dose IV can be used in immunocompromised, disseminated or CNS disease.

20 mg/kg/dose PO QID
Maximum: 3.2 grams/24h OR 800 mg/dose