Pediatric Amoxicillin-Clavulanate Dosing

NOTE

All mg/kg dosing is based on the amoxicillin component.
See important notes below around the appropriate specification of product to prescribe/dispense.

General Dosing

1 to 3 months of age:
15 mg/kg/dose PO BID
Use 25 mg/mL suspension
(approx. 4:1 amoxicillin: clavulanate)

Polymicrobial or Skin and Soft Tissue Infections

Greater than 3 months:
13 -16 mg/kg/dose PO TID
Maximum: 500 mg/dose

Less than 35 kg:
Use the 80 mg/mL suspension
(approx. 7:1 amoxicillin:clavulante)

Greater than or equal to 35 kg:
Use 500 mg tablets OR 80 mg/mL suspension
(approx. 7:1 amoxicillin:clavulante)

Dog/Cat/Human Bites

Periorbital Cellulitis

Aspiration Pneumonia

Note

Using a product with incorrect amoxicillin-clavulanate could result in sub-therapeutic clavulanate concentrations or severe diarrhea. If possible, limit clavulanate to less than 6.4 -10 mg/kg/24h to reduce GI side effects. Based upon usual dosing in pediatric patients less than 35 kg, use of the 7:1 ratio suspension provides 6.4-8.6 mg/kg/24h of clavulanate and 4:1 ratio suspension provides 11.2-15 mg/kg/24h of clavulanate.

Suggested product specification/selection:

Less than 3 months:
Use 25 mg/mL suspension
(approx. 4:1 amoxicillin: clavulanate)

Less than 35 kg:
Use the 80 mg/mL suspension
(approx. 7:1 amoxicillin:clavulante)

Greater than or equal to 35 kg:
Use 500 mg tablets OR 80 mg/mL suspension
(approx. 7:1 amoxicillin:clavulante)