Nitrofurantoin

C. diff Risk

Low

Oral Bioavailability

Excellent

Approximate Cost

Spectrum Of Activity

Dosing

100 mg PO BID (MacroBID)

0 - 29 mL/minAVOID

30+ mL/min100 mg PO BID

General Information

Common Usage

DO NOT use for pyelonephritis or bacteremia as insufficient systemic drug levels.

Adverse Effects

Interstitial pneumonitis and fibrosis esp. with prolonged use

Peripheral neuropathy

Major Interactions

Antacids decrease absorption

Pharmacology

Pregnancy category: B

Urine penetration: Therapeutic

Lung penetration: None

CSF penetration: None

Biliary penetration: None