Medium
NA
Reserved for highly resistant infections or when significant allergies restrict other options and when there is documented susceptibility
Associated with more treatment failures than alternatives and excess mortality - Black Box Warning
Avoid or use with caution in patients with tetracycline reactions
GI side effects very prominent with significant nausea and vomiting
Tetracycline related adverse events: photosensitivity, acute pancreatitis
Rash, abnormal liver enzymes
Requires Infectious Disease consultation
Documented safety concerns in bacteremia
An increase in all-cause mortality has been observed in a meta-analysis of phase 3 and 4 clinical trials in tigecycline-treated patients versus comparator.
Antimicrobial class: Tetracycline derivative
Pregnancy category: D
Average serum half life: 42.0
Lung penetration: Therapeutic
Biliary penetration: Therapeutic
