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Antimicrobials
Medium
NA
100 mg IV once, then 50 mg IV q12h
No dose adjustment
Reserved for highly resistant infections or when significant allergies restrict other options and when there is documented susceptibility
Associated with more treatment failures than alternatives and excess mortality - Black Box Warning
Avoid or use with caution in patients with tetracycline reactions
GI side effects very prominent with significant nausea and vomiting
Tetracycline related adverse events: photosensitivity, acute pancreatitis
Rash, abnormal liver enzymes
Oral contraceptives less effective
Requires Infectious Disease consultation
Documented safety concerns in bacteremia
An increase in all-cause mortality has been observed in a meta-analysis of phase 3 and 4 clinical trials in tigecycline-treated patients versus comparator.
Antimicrobial class: Tetracycline derivative
Pregnancy category: D
Average serum half life: 42.0
Lung penetration: Therapeutic
Biliary penetration: Therapeutic