Piperacillin-Tazobactam

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

Spectrum Of Activity

Dosing

Pseudomonas: 4.5 g IV q6h

Standard dose: 3.375 g IV q6h

General Information

Adverse Effects

Allergy/rash (immediate or delayed), cytopenias- esp. thrombocytopenia, eosinophilia, interstitial nephritis, abnormal liver enzymes

Major Interactions

Incr. levels of methotrexate

Additional Information

Higher doses required for antipseudomonal coverage (4.5 g IV q6h)

Pharmacology

Antimicrobial class: Ureidopenicillin with a beta-lactamase inhibitor

Pregnancy category: B