Linezolid

Restricted
Restricted

C. diff Risk

Low

Oral Bioavailability

Excellent

Approximate Cost

Spectrum Of Activity

Dosing

600 mg PO/IV BID

No dose adjustment

General Information

Common Usage

Restricted to infections caused by gram positive organisms that are resistant to vancomycin or in patients intolerant to vancomycin.

Drug Monitoring

CBC at least once/week

Visual testing for therapy >3mo or if symptoms develop on therapy

Adverse Effects

Myelosuppression (usually after 2 weeks therapy) - reversible

Peripheral/optic neuropathy with prolonged courses

Serotonin syndrome

Rash

Elevated liver enzymes

Lactic acidosis

Major Interactions

SSRI and other serotonergics/MAOIs - increased risk of serotonin syndrome

Rifampin decreases linezolid levels

Pharmacology

Antimicrobial class: Oxazolidinone

Pregnancy category: C