Doxycycline

C. diff Risk

Low

Oral Bioavailability

Excellent

Approximate Cost

Dosing

100 mg PO BID

No dose adjustment

General Information

Adverse Effects

GI upset and erosive esophagitis

Photosensitivity rash

Teeth staining

Major Interactions

Some anticonvulsants can decrease doxycycline levels

Increased digoxin levels

Increased INR with warfarin

Di- & Trivalent cations including Al, Ca, Fe, Mg (antacids, dairy products, iron supplements, some enteral feeds) - decreased absorption.

Pharmacology

Antimicrobial class: Tetracycline

Pregnancy category: D