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Guidelines
Pathogens
Antimicrobials
Low
Excellent
100 mg PO BID
No dose adjustment
GI upset and erosive esophagitis
Photosensitivity rash
Teeth staining
Some anticonvulsants can decrease doxycycline levels
Increased digoxin levels
Increased INR with warfarin
Di- & Trivalent cations including Al, Ca, Fe, Mg (antacids, dairy products, iron supplements, some enteral feeds) - decreased absorption.
Antimicrobial class: Tetracycline
Pregnancy category: D