Fosfomycin

Restricted
Restricted

C. diff Risk

Low

Oral Bioavailability

Moderate

Approximate Cost

Spectrum Of Activity

Dosing

Uncomplicated cystitis: 3 g PO once

Complicated cystitis: 3 g PO every 3 days x 3 doses

Dose post-dialysis

General Information

Common Usage

Restricted to treatment of acute uncomplicated cystitis caused by susceptible organisms with demonstrated resistance and/or intolerance to all other oral agents.

DO NOT use for pyelonephritis or bacteremia as insufficient systemic drug levels.

Adverse Effects

  • GI upset, esp. diarrhea

  • ¬†Headache

  • ¬†Eosinophilia, neutropenia

  • ¬†Hypokalemia

Major Interactions

No significant

Additional Information

IV formulation not available in Canada

Pharmacology

Antimicrobial class: Phosphonic acid derivative

Pregnancy category: B