Spectrum: Local Antimicrobial Stewardship, for Fraser Health

Fosfomycin

Restricted
Restricted

C. diff Risk

Low

Oral Bioavailability

Moderate

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Adult

Uncomplicated cystitis: 3 g PO once

Complicated cystitis: 3 g PO every 3 days x 3 doses

Renal

Dose post-dialysis

General Information

Common Usage

Common Usage

Restricted to treatment of acute uncomplicated cystitis caused by susceptible organisms with demonstrated resistance and/or intolerance to all other oral agents.

DO NOT use for pyelonephritis or bacteremia as insufficient systemic drug levels.

Adverse Effects

Adverse Effects

  • GI upset, esp. diarrhea

  •  Headache

  •  Eosinophilia, neutropenia

  •  Hypokalemia

Major Interactions

Major Interactions

No significant

Additional Information

Additional Information

IV formulation not available in Canada

Pharmacology

Pharmacology

Antimicrobial class: Phosphonic acid derivative

Pregnancy category: B