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Guidelines
Pathogens
Antimicrobials
Low
Moderate
Uncomplicated cystitis: 3 g PO once
Complicated cystitis: 3 g PO every 3 days x 3 doses
Dose post-dialysis
Restricted to treatment of acute uncomplicated cystitis caused by susceptible organisms with demonstrated resistance and/or intolerance to all other oral agents.
DO NOT use for pyelonephritis or bacteremia as insufficient systemic drug levels.
GI upset, esp. diarrhea
Headache
Eosinophilia, neutropenia
Hypokalemia
No significant
IV formulation not available in Canada
Antimicrobial class: Phosphonic acid derivative
Pregnancy category: B