Clindamycin

C. diff Risk

High

Oral Bioavailability

Excellent

Approximate Cost

Spectrum Of Activity

Dosing

300-450 mg PO QID or 450-600 mg PO TID

600-900 mg IV q8h

No dose adjustment

General Information

Drug Monitoring

None specific - monitor for diarrhea.

Adverse Effects

High risk of Clostridium difficile infection.

Major Interactions

Muscle relaxants, e.g. atracurium, baclofen, diazepam.

St. Johns Wort

Pharmacology

Antimicrobial class: Lincosamide

Pregnancy category: B