Fluconazole

C. diff Risk

Low

Oral Bioavailability

Excellent

Approximate Cost

Spectrum Of Activity

Dosing

100-400 mg PO/IV daily

General Information

Drug Monitoring

Consider QTc monitoring if concomitant drugs affecting the interval or elevated baseline measurement.

Adverse Effects

  • Drug interactions

  •  QTc prolongation

  •  Hepatic enzyme abnormalities

  •  Rash

  •  Alopecia

  • GI upset

  • Check LFTs within a week of starting treatment

Major Interactions

Many via CYP450 - review specific patient medications

Fluconazole increases levels of phenytoin, cyclosporine, tacrolimus, warfarin, oral hypoglycemics

Risk when combining with other QTc prolonging medications

Pharmacology

Antimicrobial class: Triazole antifungal, decreases ergosterol synthesis

Pregnancy category: C