Low
Excellent
Consider QTc monitoring if concomitant drugs affecting the interval or elevated baseline measurement.
Drug interactions
QTc prolongation
Hepatic enzyme abnormalities
Rash
Alopecia
GI upset
Check LFTs within a week of starting treatment
Many via CYP450 - review specific patient medications
Fluconazole increases levels of phenytoin, cyclosporine, tacrolimus, warfarin, oral hypoglycemics
Risk when combining with other QTc prolonging medications
Antimicrobial class: Triazole antifungal, decreases ergosterol synthesis
Pregnancy category: C
