Antimicrobials
Fluconazole

Fluconazole

Low
Excellent

Spectrum of Activity

Dosing

General Information

Consider QTc monitoring if concomitant drugs affecting the interval or elevated baseline measurement.

  • Drug interactions
  •  QTc prolongation
  •  Hepatic enzyme abnormalities
  •  Rash
  •  Alopecia
  • GI upset
  • Check LFTs within a week of starting treatment

Many via CYP450 - review specific patient medications

Fluconazole increases levels of phenytoin, cyclosporine, tacrolimus, warfarin, oral hypoglycemics

Risk when combining with other QTc prolonging medications

Antimicrobial class: Triazole antifungal, decreases ergosterol synthesis

Pregnancy category: C