4-6 mg/kg IV q24h
Targeted therapy of resistant gram positive infections with MRSA (particularly when MIC>=2) and VRE including endovascular infection.
Creatine kinase weekly.
Myopathy including rhabdomyolysis, GI side effects common, rash, phlebitis, increased INR.
Statins and fibrates: monitor creatine kinase or hold while on daptomycin therapy (increased myopathy).
Infectious Disease consultation recommended.
Inactivated by pulmonary surfactant and therefore insufficient for pulmonary infection.
Antimicrobial class: Cyclic lipopeptide, depolarizes bacterial cell membrane
Pregnancy category: B