Oseltamivir

C. diff Risk

None

Oral Bioavailability

Excellent

Approximate Cost

Dosing

Treatment: 75 mg PO BID x 5 days

Prophylaxis: 75 mg PO daily x 10 days

Duration may be extended in select circumstances.

General Information

Common Usage

Treatment and prophylaxis of influenza

Adverse Effects

  • GI upset common

  • Rare - Stevens Johnson

  • Neuropsychiatric side effects reported

Major Interactions

No significant

Additional Information

Higher doses have not been shown to be superior but may be considered in critically ill or obese patients i.e. 150mg PO BID.

Pharmacology

Antimicrobial class: Antiviral - neuraminidase inhibitor

Pregnancy category: C