250-500 mg q24h
no adjustment required
Community acquired pneumonia, Pertussis, upper respiratory tract infections, Chlamydial infections, mycobacterial infections, Mycobacterium avium complex (MAC) prophylaxis in HIV patients.
Monitor QTc in patients with increased risk
Prolongation of QTc interval - Association with increased cardiovascular mortality in observational studies.
Prolonged half life may contribute to macrolide resistance.
Other drugs that prolong QTc
Increases cyclosporine levels
May increase digoxin levels
Statins increased risk of rhabdomyolysis
Increases INR with warfarin
Very high tissue penetration and concentration intracellularly means in vivo activity may not be predicted by in vitro testing - i.e. Salmonella spp
May exacerbate muscle weakness in persons with myasthenia gravis. Use with caution.
Antimicrobial class: Macrolide
Pregnancy category: B