Imipenem

Restricted
Restricted

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

Spectrum Of Activity

Dosing

500 mg IV q6h

General Information

Adverse Effects

Immediate and delayed-type allergy

GI disturbance

Cytopenias, positive Coombs

Liver enzyme abnormalities

CNS effects including confusional states and seizures

Major Interactions

May decrease serum concentrations of valproic acid

Ganciclovir/valganciclovir - may increase risk of seizures

Cyclosporine - may enhance neurotoxic effects of Imipenem

Pharmacology

Antimicrobial class: Carbapenem

Pregnancy category: C