Amoxicillin-Clavulanate

C. diff Risk

Medium

Oral Bioavailability

Excellent

Approximate Cost

Dosing

875-125 mg one tab PO BID
OR 500-125 mg one tab PO TID

General Information

Adverse Effects

Hepatotoxicity due to clavulanate - usually mild, liver failure is rare

Allergy/rash (immediate or delayed), cytopenias, diarrhea. Note EBV related rash.

Major Interactions

Increased risk of rash with allopurinol

Pharmacology

Antimicrobial class: Aminopenicillin + Beta-lactamase inhibitor

Pregnancy category: B