Ampicillin
Renal

Renal

Standard Dose (CrCl)

≥50 mL/min

1-2 g IV q6h

30 to <50 mL/min

1-2 g IV q8h

15 to <30 mL/min

1-2 g IV q12h

<15 mL/min

1-2 g IV q24h

Intermittent Hemodialysis (thrice weekly)

1 g IV q12h (give at least one dose post HD)

Peritoneal Dialysis

500 mg-1 g IV q12h

CVVHDF

1 g IV q8h

High Dose (CrCl)

High dosing indicated for deep-seated infections (e.g. endocarditis, Enterococcus faecalis bacteremia)

≥50 mL/min

2 g IV q4h

30 to <50 mL/min

2 g IV q6h

15 to <30 mL/min

2 g IV q8h

<15 mL/min

2 g IV q12h

Intermittent Hemodialysis (thrice weekly)

2 g IV q12h (give at least one dose post HD)

Peritoneal Dialysis

2 g IV q12h

CVVHDF

2 g IV q6h