Antimicrobials
Nitrofurantoin

Nitrofurantoin

Low
Good (70 to 90%)
$

Spectrum of Activity

Dosing

General Information

Uncomplicated cystitis in patients with normal renal function

  • Interstitial pneumonitis and fibrosis esp. with prolonged use
  • Peripheral neuropathy

Other Available Outpatient Strengths
Suspension: 25 mg/5 mL

Prisma Health Inpatient Formulary
Capsule: 25 mg, 100 mg

Other Available Outpatient Strengths
Capsule: 50 mg

  • The capsule can be opened and mixed with drink or food of choice at time of administration
  • Does not provide adequate renal concentrations for treatment of systemic infections (i.e urosepsis, pyelonephritis); appropriate for cystitis and/or urinary prophylaxis

Antimicrobial class: Nitrofuran

Average serum half life:

  • No pediatric data
  • Adults: 20 to 60 minutes and is prolonged with renal impairment

Route of Elimination: As metabolites and unchanged drug (40%) in the urine and small amounts in the bile; renal excretion is via glomerular filtration and tubular secretion