Treatment
Prophylaxis
CBC with differential, platelet count, PT, renal and hepatic function tests periodically. If using in patient < 30 days old, monitor bilirubin at baseline to ensure < 5 mg/dL.
Calcium containing IV solutions:
IM ceftriaxone may be given with 1% lidocaine to minimize pain at injection site.
Antimicrobial class: Parenteral Cephalosporin - 3rd Generation
Pregnancy category: B
Average serum half life:
Biliary penetration: Good (40-50% unchanged excreted in bile)
CSF penetration: Good (8-16%). Higher concentrations when meninges are inflamed
Lung penetration: Good
Urine penetration: Good (33-67% unchanged)
Route of Elimination: Unchanged in the urine (33-67%) by glomerular filtration and in feces via bile