Antimicrobials
Doxycycline

Doxycycline

Low
Excellent (90 to 100%)
IV$$$ PO$

Dosing

General Information

  • Skin and soft tissue infection

  • Methicillin resistant staphylococcus aureus infections

  • Community acquired pneumonia

  • Malaria prophylaxis

  • Zoonoses

  • Skin and soft tissue infections

  • Rickettsia and other tick-borne diseases

  • Chlamydia

  • Mycoplasma

  • GI upset and erosive esophagitis

  • Photosensitivity rash

  • Teeth staining (less than tetracycline)

  • Antacids, bismuth, multivitamin and mineral supplements - decreased absorption
  • Barbiturates
  • Carbamazepine
  • Fosphenytoin/phenytoin
  • Penicillins

Prisma Health Inpatient Formulary
Suspension (monohydrate): 25 mg/5 mL

Prisma Health Inpatient Formulary
Capsule (hyclate): 100 mg

Other Available Outpatient Strengths
Capsule (hyclate): 50 mg
Capsule (monohydrate): 50 mg, 75 mg, 100 mg, 150 mg
Delayed-release capsule (monohydrate): 40 mg
Delayed-release tablet (hyclate): 50 mg, 60 mg, 75 mg, 80 mg, 100 mg, 150 mg, 200 mg
Tablet (hyclate): 20 mg, 50 mg, 75 mg, 100 mg, 150 mg
Tablet (monohydrate): 50 mg, 75 mg, 100 mg, 150 mg

  • Avoid iron, magnesium, calcium, and dairy products for at least one hour before or two hours after doxycycline administration

  • Take with food to lessen nausea

  • Take with lots of water and not before bed to decrease occurence of esophagitis

Antimicrobial class: Tetracycline

Pregnancy category: D

Average serum half life: 18 hours

Biliary penetration: Good

CSF penetration: Poor

Lung penetration: Good

Urine penetration: Good

Route of Elimination: In the urine (40%) and feces (30%)

Metabolism: Partially inactivated in GI tract by chelate formation