Azithromycin

C. diff Risk

Medium

Oral Bioavailability

Excellent

Approximate Cost

>$4/day (Oral)

Spectrum Of Activity

Dosing

10 mg/kg/dose IV/PO once daily for 5 days

Daily Dose: 10 mg/kg/day

Maximum Daily Dose: 500 mg/day

Dosing Frequency: IV divided q24h

Used for CAP due to Mycoplasma or Chlamydophila

Daily Dose: 10 mg/kg/day on day 1 then 5 mg/kg/day for days 2 - 5

Maximum Daily Dose: 500 mg/day for day 1, 250 mg/day for days 2 - 5

Dosing Frequency: PO divided Once Daily

Usual duration: 5 days

Daily Dose

  • Less than 6 months:
    10 mg/kg/day

  • Greater than 6 months:
    10 mg/kg/day on day 1 then 5 mg/kg/day for days 2- 5

Maximum Daily Dose:

500 mg/day for day 1

250 mg/day for days 2 - 5

Dosing Frequency: PO divided Once Daily

Suspected or confirmed due to Chlamydia trachomatis. Note this should always include concurrent treatment for N. gonorrhea

Daily Dose: 12 - 15 mg/kg/dose as a single dose

Maximum Daily Dose: 1 g/dose

Dosing Frequency: PO as a single dose

General Information

An association between orally administered azithromycin with infantile hypertrophic pyloric stenosis (IHPS) has been reported in infants younger than 1 month.

However, azithromycin is still the drug of choice for treatment or prophylaxis of pertussis if the risk of developing severe pertussis outweighs the potential risk of IHPS.

Concentration: 40 mg/mL

Taste: Bitter taste

Not all strengths of oral liquids are listed nor be available on the CHEO Formulary

  • 250 mg

  • 600 mg

Tablets or capsules are preferred especially over an unpleasant tasting oral liquid.

Not all strengths of oral tablets/capsules are listed and they are not all available on the CHEO Formulary.