Amoxicillin

C. diff Risk

Low

Oral Bioavailability

Excellent

Approximate Cost

$1-2/day (Oral)

Spectrum Of Activity

Dosing

Dosing is for neonates <42 weeks gestational age OR term to 4 weeks of age

20 - 30 mg/kg/day divided Q12H

10 - 15 mg/kg/day once daily

Should not be used for infants > 2 months of age

Daily Dose: 45 - 60 mg/kg/day

Maximum Daily Dose: 4000 mg/day

Dosing Frequency: PO divided TID

Note

  • Treatment of pneumonia, sinusitis or other indications should be with a three times a day (TID) dosing schedule.

  • Since the half-life of amoxicillin is one hour, a TID schedule will achieve higher levels for a more prolonged period of time.

  • Although TID dosing for AOM can also be used, BID dosing of amoxicillin has been approved for treatment of uncomplicated acute otitis media, albeit with higher doses (see BID dosing below).

Daily Dose: 75 - 90 mg/kg/day

Maximum Daily Dose: 4000 mg/day

Dosing Frequency: PO divided BID for AOM

Note

  • BID dosing of amoxicillin should only be used for treatment of uncomplicated AOM.

General Information

Concentration: 50 mg/mL

Taste: Very good

Not all strengths of oral liquids are listed nor be available on the CHEO Formulary

  •  250 mg

  •  500 mg

Tablets or capsules are preferred especially over an unpleasant tasting oral liquid.

Not all strengths of oral tablets/capsules are listed and they are not all available on the CHEO Formulary.