Reserved for highly resistant infections or when significant allergies restrict other options and when there is documented susceptibility.
Associated with more treatment failures than alternatives and excess mortality - Black Box Warning.
Oral contraceptives less effective.
Requires Infectious Disease consultation.
Documented safety concerns in bacteremia especially.
Antimicrobial class: Tetracycline derivative
Pregnancy category: D
Average serum half life: 42 hours
Lung penetration: Therapeutic
Biliary penetration: Therapeutic