Candida infections both mucocutaneous and invasive - i.e. Candidemia.
Cryptococcus and Coccidioides infections.
Antifungal prophylaxis in immunocompromised.
Consider QTc monitoring if concomitant drugs affecting the interval or elevated baseline measurement.
Drug interactions
QTc prolongation
Hepatic enzyme abnormalities
Rash
Alopecia
GI upset
Many via CYP450. Suggest review specific patient medications.
Fluconazole increases levels of phenytoin, cyclosporine, tacrolimus, warfarin, oral hypoglycemics.
Risk when combining with other QTc prolonging medications.
Antimicrobial class: Triazole antifungal
Pregnancy category: C
Average serum half life: 20 hours
Biliary penetration: Therapeutic
CSF penetration: Therapeutic
Lung penetration: Therapeutic
Urine penetration: Therapeutic