eGFR 0- 30eGFR > 30500mg IV q24h1g IV q24h
500mg IV daily
Dose after dialysis on HD days
1g IV q24h
Must be approved by Infectious Diseases
This antimicrobial is restricted to Infectious Diseases, Adult Critical Care, Vascular Surgery and General Surgery
Targeted therapy of ESBL infections and other resistant Gram negative infections.
Empiric therapy when broad spectrum of carbapenems is desired without the need for anti-pseudomonal activity.
Immediate and delayed-type allergy
Cytopenias, eosinophilia, positive Coombs
Liver enzyme abnormalities
Seizure risk lower than other carbapenems
Must be approved by Infectious Diseases.
Antimicrobial class: Carbapenem
Pregnancy category: B
Average serum half life: 4 hours
Biliary penetration: Moderate
Lung penetration: Therapeutic
Urine penetration: Therapeutic