C difficile risk
Oral Bioavailability


eGFR 0- 30eGFR > 30500mg IV q24h1g IV q24h

500mg IV daily

Dose after dialysis on HD days

1g IV q24h

Must be approved by Infectious Diseases

This antimicrobial is restricted to Infectious Diseases, Adult Critical Care, Vascular Surgery and General Surgery

General Information

Targeted therapy of ESBL infections and other resistant Gram negative infections.

Empiric therapy when broad spectrum of carbapenems is desired without the need for anti-pseudomonal activity.

  • Immediate and delayed-type allergy

  • GI disturbance

  • Cytopenias, eosinophilia, positive Coombs

  • Liver enzyme abnormalities

  • Seizure risk lower than other carbapenems

Must be approved by Infectious Diseases.

Antimicrobial class: Carbapenem

Pregnancy category: B

Average serum half life: 4 hours

Biliary penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic