C. diff Risk


Oral Bioavailability


Approximate Cost


No dosage adjustments required

Usual dosage
1-2g IV q24h

Community-acquired pneumonia
1-2g IV q24h

Community-acquired intra-abdominal infection
1-2g IV q24h

Bacterial Meningitis OR Intra-cranial abscess
2g IV q12h

Infective Endocarditis
2g IV q12-24h

2g IV q24h

General Information

Common Usage

Ceftriaxone is commonly used as empiric treatment for bacterial meningitis, community-acquired pneumonia and community-acquired intra-abdominal infections.

Adverse Effects

  • Allergy/rash

  • Phlebitis

  • Cytopenias

  • Hepatic & renal laboratory abnormalities

  • Pseudocholelithiasis

  • Clostridium difficile associated diarrhea

Major Interactions

Increased risk of QT prolongation in patients given both ceftriaxone and lansoprazole.


Antimicrobial class: Parenteral Cephalosporin - 3rd Generation

Pregnancy category: B

Average serum half life: 8 hours

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic