C. diff Risk


Oral Bioavailability



No dosage adjustment required

Usual Dosing
300-450mg PO q6h
600mg IV q8h

Necrotizing SSTI or toxic shock syndrome
900mg IV q8h

General Information

High risk of Clostridium difficile infection

Anaerobic infections above the diaphragm, especially dental infection.

Gram positive skin and soft tissue infections including necrotizing fasciitis as an adjunctive agent to a beta lactam for reducing toxin production.

Skin & soft tissue infections involving susceptible MRSA.

Susceptible infections and surgical prophylaxis in setting of IgE mediated beta-lactam allergy.

For decreasing toxin production in toxic shock syndrome.

None specific. Monitor for diarrhea.

Muscle relaxants, e.g., atracurium, baclofen, diazepam.

St. Johns Wort

Antimicrobial class: Lincosamide

Pregnancy category: B

Average serum half life: 2.4 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Poor