300-450mg PO q6h
600mg IV q8h
Necrotizing SSTI or toxic shock syndrome
900mg IV q8h
No dosage adjustment required
Anaerobic infections above the diaphragm, especially dental infection.
Gram positive skin and soft tissue infections including necrotizing fasciitis as an adjunctive agent to a beta lactam for reducing toxin production.
Skin & soft tissue infections involving susceptible MRSA.
Susceptible infections and surgical prophylaxis in setting of IgE mediated beta-lactam allergy.
For decreasing toxin production in toxic shock syndrome.
None specific. Monitor for diarrhea.
High risk of Clostridium difficile infection
Muscle relaxants, e.g., atracurium, baclofen, diazepam.
St. Johns Wort
Antimicrobial class: Lincosamide
Pregnancy category: B
Average serum half life: 2.4 hours
Urine penetration: Poor
Lung penetration: Therapeutic
Biliary penetration: Therapeutic
CSF penetration: Poor