125mg PO QID for 14 days.
250mg in 100mL of NS by rectal enema q6h
No dosing adjustments required
Only indication is in the therapy of C. difficile infection, particularly recurrent or severe disease
Possibility of accumulation in severe renal dysfunction.
No oral absorption.
May increase vancomycin resistant Enterococci colonization in the gut.
Antimicrobial class: Glycopeptide
Pregnancy category: B
Average serum half life: 0 hours
Urine penetration: None
Biliary penetration: None
Lung penetration: None
CSF penetration: None