Cefepime

Restricted
Restricted

C. diff Risk

High

Oral Bioavailability

NA

Approximate Cost

Dosing

Usual dosing
2g IV q8-12h

Febrile neutropenia
2g IV q8h

General Information

Common Usage

Cefepime is a broad-spectrum antimicrobial with Gram positive and Gram negative coverage including activity against Pseudomonas spp.

Cefepime is often used in the treatment of febrile neutropenia and nosocomial infections involving multi-drug resistant organisms.

Use must be approved by Infectious Diseases

Adverse Effects

  • Allergy/rash

  • Positive Coombs test

  • Cytopenias

  • Clostridium difficile associated diarrhea

Additional Information

Use must be approved by Infectious Diseases

Pharmacology

Antimicrobial class: 4th Generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Biliary penetration: Moderate

CSF penetration: Therapeutic

Urine penetration: Therapeutic

Lung penetration: Therapeutic