Spectrum: Clinical Decision Support for Infectious Disease, for SHA - Saskatoon Area
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Antimicrobials Antimicrobials

Cloxacillin

C difficile risk
Medium
Oral Bioavailability
NA

Spectrum Of Activity

Spectrum Of Activity

Dosing

Renal

No dosage adjustments required

Adult

General dosing
2g IV q4-6h

MSSA bacteremia OR Endocarditis
2g IV q4h

MSSA pneumonia
2g IV q4h

Oral dosing - Skin and Soft Tissue infections ONLY
500mg PO QID

General Information

Common Usage

Treatment of MSSA infections

Adverse Effects

  • Allergy (immediate or delayed)

  • Cytopenias

  • Eosinophilia

  • Interstitial nephritis

  • Abnormal liver enzymes

  • Phlebitis at injection site in a peripheral vein

Major Interactions

Can increase methotrexate levels.

Decrease mycophenolate levels.

Tetracyclines can diminish cloxacillin activity.

Pharmacology

Antimicrobial class: Antistaphylococcal Penicillin

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic