Spectrum: Local Antimicrobial Stewardship, for SHA - Saskatoon Area

Cloxacillin

C. diff Risk

Medium

Oral Bioavailability

NA

Spectrum Of Activity

Spectrum Of Activity

Antibiogram Data

Dosing

Renal

No dosage adjustments required

Adult

General dosing
2g IV q4-6h

MSSA bacteremia OR Endocarditis
2g IV q4h

MSSA pneumonia
2g IV q4h

Oral dosing - Skin and Soft Tissue infections ONLY
500mg PO QID

General Information

Adverse Effects

  • Allergy (immediate or delayed)

  • Cytopenias

  • Eosinophilia

  • Interstitial nephritis

  • Abnormal liver enzymes

  • Phlebitis at injection site in a peripheral vein

Common Usage

Treatment of MSSA infections

Major Interactions

Can increase methotrexate levels.

Decrease mycophenolate levels.

Tetracyclines can diminish cloxacillin activity.

Pharmacology

Antimicrobial class: Antistaphylococcal Penicillin

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic