No dosage adjustments required
General dosing 2g IV q4-6h
MSSA bacteremia OR Endocarditis 2g IV q4h
MSSA pneumonia 2g IV q4h
Oral dosing - Skin and Soft Tissue infections ONLY 500mg PO QID
Treatment of MSSA infections
Allergy (immediate or delayed)
Cytopenias
Eosinophilia
Interstitial nephritis
Abnormal liver enzymes
Phlebitis at injection site in a peripheral vein
Can increase methotrexate levels.
Decrease mycophenolate levels.
Tetracyclines can diminish cloxacillin activity.
Antimicrobial class: Antistaphylococcal Penicillin
Pregnancy category: B
Average serum half life: 1 hour
Biliary penetration: Moderate
Lung penetration: Therapeutic
Urine penetration: Therapeutic