C difficile risk
Oral Bioavailability


eGFR 0 - 10eGFR 10 - 50eGFR > 50500mg PO q12-24h500mg PO q12h500mg PO q6h

500mg PO q12-24h

Dose after dialysis on hemodialysis days

Usual dose
500mg PO QID

General Information

Cephalexin is commonly used in the treatment of skin and soft tissue infections.

  • Allergy/rash

  • Positive Coombs test

  • Cytopenias

  • Hepatic & renal laboratory abnormalities

  • Clostridium difficile associated diarrhea

Increases metformin levels

Antimicrobial class: First Generation Cephalosporin.

Pregnancy category: B

Biliary penetration: Moderate

CSF penetration: Poor

Lung penetration: Moderate

Urine penetration: Therapeutic