Norfloxacin

C. diff Risk

High

Oral Bioavailability

Moderate

Approximate Cost

Dosing

Adult

Spontaneous bacterial peritonitis prophylaxis
400mg PO daily

General Information

Common Usage

Prophylaxis of spontaneous bacterial peritonitis.

Drug Monitoring

Monitor QTc in patients with increased risk

Adverse Effects

  • QTc prolongation

  • Dysglycemia

  • Rash

  • Tendinopathy and rupture

  • GI upset

  • Weakness exacerbation in myasthenia gravis

  • CNS toxicity including confusion, psychosis

Major Interactions

Other QTc prolonging agents.

Divalent cations - Decreased absoprtion.

Methadone - Increased seizures.

Thyroid replacement - Decreases T.

Warfarin - Increased INR.

Pharmacology

Antimicrobial class: Fluoroquinolone

Pregnancy category: C

Average serum half life: 4 hours

Urine penetration: Therapeutic

CSF penetration: Poor

Biliary penetration: Therapeutic