Oseltamivir

C. diff Risk

None

Oral Bioavailability

Excellent

Spectrum Of Activity

Dosing

eGFR < 30eGFR 30 - 60eGFR > 6030mg PO daily30mg PO BID75 mg PO BID

75 mg PO immediately x 1 dose then 30 mg after every HD session for 2 more doses

Note: Assumes two hemodialysis sessions falling within the 5-day period

30 mg PO daily X 5 days

Usual dose
75mg PO BID

Prophylaxis
75mg PO daily

General Information

Higher doses (150mg PO BID) have not been shown to be superior but may be considered in critically ill or obese patients.

  • GI upset common

  • Rare - Stevens Johnson

  • Neuropsychiatric side effects reported

Treatment and prophylaxis of influenza

No significant interactions

Antimicrobial class: Antiviral - Neuraminidase inhibitor

Pregnancy category: C

Average serum half life: 2 hours

Lung penetration: Therapeutic