C difficile risk
Oral Bioavailability


eGFR < 30eGFR 30 - 60eGFR > 6030mg PO daily30mg PO BID75 mg PO BID

75 mg PO immediately x 1 dose then 30 mg after every HD session for 2 more doses

Note: Assumes two hemodialysis sessions falling within the 5-day period

30 mg PO daily X 5 days

Usual dose
75mg PO BID

75mg PO daily

General Information

Treatment and prophylaxis of influenza

  • GI upset common

  • Rare - Stevens Johnson

  • Neuropsychiatric side effects reported

No significant interactions

Higher doses (150mg PO BID) have not been shown to be superior but may be considered in critically ill or obese patients.

Antimicrobial class: Antiviral - Neuraminidase inhibitor

Pregnancy category: C

Average serum half life: 2 hours

Lung penetration: Therapeutic