Fosfomycin

Restricted
Restricted

C. diff Risk

Low

Oral Bioavailability

Moderate

Approximate Cost

Dosing

Female, Uncomplicated UTI
3g PO x 1 dose

Complicated or male UTI
3g PO q2-3days x 3 doses

Intermittent Dialysis
Dose post-hemodialysis

General Information

Common Usage

Urinary Tract Infection, especially involving ESBL producing organisms

Offlabel - Prostatitis

NOT recommended in pyelonephritis

Adverse Effects

  •  GI upset, especially diarrhea

  •  Headache

  •  Eosinophilia, neutropenia

  •  Hypokalemia

Major Interactions

No significant interactions

Pharmacology

Antimicrobial class: Phosphonic acid derivative

Pregnancy category: B

Average serum half life: 6 hours

Urine penetration: Therapeutic