Moxifloxacin

C. diff Risk

High

Oral Bioavailability

Excellent

Approximate Cost

Dosing

Adult

400mg IV/PO daily

Hepatic

No dose adjustment required

Renal

No dose adjustment required

General Information

Common Usage

Pneumonia including CAP, HAP, aspiration

Drug Monitoring

Monitor QTc in patients with increased risk

Adverse Effects

  • QTc prolongation

  • Dysglycemia

  • Rash

  • Tendinopathy and rupture

  • GI upset

  • Weakness exacerbation in myasthenia gravis

  • CNS toxicity including confusion, psychosis

Major Interactions

QTc prolongation - Increased risk with other agents that prolong QTc

Divalent cations including Ca, Mg - Decreased absorption

Warfarin - Increased INR

Rifampin - Decrease moxifloxacin levels

Pharmacology

Antimicrobial class: Fluoroquinolone

Pregnancy category: C

Average serum half life: 12 hours

Urine penetration: Poor

CSF penetration: Therapeutic

Biliary penetration: Therapeutic

Lung penetration: Therapeutic